Follow I-40 WEST/U.S. 65 NORTH from Little Rock to EXIT 125 in Conway where U.S. 65 continues NORTH. Turn right off the exit ramp onto U.S. 65 NORTH, then continue NORTH on U.S. 65 to U.S. 54 in MISSOURI. Turn right onto U.S. 54 EAST towards MACKS CREEK.
Take U.S. 54 EAST (towards FULTON), from Jefferson City, to I-70 EAST to ST. LOUIS.
Take I-70 EAST to I-64 EAST to LOUISVILLE, via I-270 NORTH (EXIT 232A off I-70) and I-255 SOUTH to bypass ST. LOUIS (EXIT 7 off I-270 in ILLINOIS to get onto I-255 SOUTH ; EXIT 20 off I-255 to get onto I-64 EAST to LOUISVILLE).
Take I-64 EAST to I-57 SOUTH to MEMPHIS, at Mt. Vernon, IL.
Continue on I-57 SOUTH to I-24 EAST to NASHVILLE at EXIT 44.
Take I-24 EAST to I-65 SOUTH to HUNTSVILLE at DOWNTOWN NASHVILLE, TENNESSEE.
Take I-65 SOUTH, thru Birmingham, AL, to I-85 NORTH to ATLANTA at EXIT 171 in MONTGOMERY, ALABAMA.
Take I-85 NORTH, thru Montgomery, to U.S. 231, via AL-271 TAYLOR RD (take EXIT 9 off I-85 to get onto AL-271 TAYLOR RD - SOUTH towards U.S. 231 ; take AL-271 TAYLOR RD - SOUTH to JCT U.S. 231, where you will turn left onto U.S. 231 SOUTH towards DOTHAN).
Take U.S. 231 SOUTH, thru Dothan, to I-10 EAST to TALLAHASSE, at JCT I-10 in FLORIDA.
From Kansas City, MO to the Blue Water Bridge border x-ing @ PORT HURON, MI it is 850 miles taking this route:
Take I-35 NORTH (towards DES MOINES), from Kansas City, to I-80 EAST to DAVENPORT, at Des Moines, IOWA.
Continue on I-80 EAST to I-94 EAST to DETROIT, in northwestern INDIANA, outside of Chicago.
Continue on I-94 EAST to I-69 NORTH to LANSING off EXIT 108 in MICHIGAN.
Take I-69 NORTH (& EAST, past Lansing), to CANADA, via the BLUE WATER BRIDGE (toll), crossing from PORT HURON, MICHIGAN, U.S.A. into SARNIA (technically Point Edward), ONTARIO, CANADA.
From Sarnia, ON to Montréal, QC, it is 820 km (510 miles) taking this route:
From Sarnia, you will continue HIGHWAY 402 - EAST towards LONDON.
Take HIGHWAY 402 - EAST to HIGHWAY 401 - EAST to TORONTO, near London.
Take HIGHWAY 401 - EAST, thru Toronto, to QUÉBEC, where the highway will continue as AUTOROUTE 20 - EST.
Continue on AUTOROUTE 20 - EST to AUTOROUTE 40 - EST to MONTRÉAL off SORTIE [exit] 29, and then take AUTOROUTE 40 - EST to Montréal. Or, if you are going to Montréal CENTRE-VILLE (the city centre), stay on AUTOROUTE 20 - EST to Montréal.