Answer: There is alot of factors in this equation. Such as where in West Palm Beach you are starting at and how far into the Keys you are looking to go. However if Key West is your destination then it is approximately 233 miles and would take 4 1/2 hours driving time to get there.
Answer: The distance between Miami Florida and West Palm Beach is around 140 - 155 miles. Driving on the Interstate you can do it in around 1 hour - 2 hours. Miami is 70.64 miles from West Palm Beach, by car the journey would take 1 hour and 19 minutes according to MapQuest.