Answer: The driving distance between Niagara, NY and New York, NY is 409 miles. The driving time would be approximately 6 hours, 30 minutes if you were to drive non-stop in good conditions. (The driving time does not take into consideration conditions such as weather, road work and rush hour traffic in urban areas.)
Answer: 165 miles taking the New York (state) THRUWAY (toll) EAST on I-90 to the ALBANY vicinity, then SOUTH on I-87, from Albany, to NEW YORK CITY. I-87 becomes the MAJ. DEEGAN EXPWY as you enter New York City.