Answer: The driving distance between Poughkeepsie, NY and Amsterdam, NY is 110 miles. The driving time would be approximately 2 hours if you were to drive non-stop in good conditions. (The driving time does not take into consideration conditions such as weather, road work and rush hour traffic in urban areas.)
Answer: 613 miles (986 kilometres) taking this route:
Take A2 UTRECHT from Amsterdam to A67 to VENLO in Eindhoven.
Take A67 to AUTOBAHN (A)61 to MÖNCHENGLADBACH (Deutschland [Germany]) at AFRIT (EXIT) 41 in VENLO. Follow signs to A61 to MÖNCHENGLADBACH. You will have to drive around the outskirts of Venlo in order to connect to A61.
Once you have crossed into DEUTSCHLAND, you will follow A61 to A6 NÜREMBURG.
Take A6 across Germany to ČESKÁ REPUBLIKA (CZECH REPUBLIC). You will be crossing at the WAIDHAUS-ROZVADOV border crossing.
Once you are in the Czech Republic, continue on D5 (motorway) (toll road) to PRAHA (PRAGUE).