Answer: The driving distance between Miami, FL and Tampa, FL is approximately 280 miles. The driving time would be approximately 4 hours 30 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
Take I-75 NORTH from Tampa all the way up to I-74 WEST via I-275 WEST around Cincinnati (EXIT 185 off I-75 in northern KENTUCKY to get onto I-275 WEST; EXIT 25 off I-275 in OHIO to get onto I-74 WEST to INDIANAPOLIS). To bypass Macon, take I-475 NORTH (EXIT 156 in GEORGIA). To bypass Atlanta, take I-285 WEST BYPASS (EXIT 238B off I-75 in GEORGIA to get onto I-285 WEST BYPASS; EXIT 20 off I-285 to get back onto I-75, follow signs to I-75 NORTH to CHATTANOOGA).
Take I-74 WEST to I-65 NORTH to CHICAGO via I-465 NORTH (and WEST) and I-865 WEST (EXIT 25 off I-465) to bypass Indianapolis.
Take I-65 NORTH to I-90 TOLL ROAD to ILLINOIS and OHIO at EXIT 262 at where I-65 ENDS in Chicagoland in Indiana.
Take I-90 WEST along the TOLL ROAD in Indiana, and then along the Chicago SKYWAY in ILLINOIS to I-94 WEST in Chicago.
Continue on I-94 WEST to IL-137 - BUCKLEY RD off I-94 - (Tri-State) TOLLWAY north of the city of Chicago proper.
Turn right off the exit ramp onto IL-137 EAST. Take IL-137 EAST to the Great Lakes Naval Training Center.