Answer: 99 miles or 159.29 Kilometers geographically 117 miles on the I-10 W. It would take you 2 hours and 7 minutes in ideal conditions to drive. Although I doubt you would be going on foot (just an interesting fact) it would take you 1 day and 11 hours if you were traveling a little more than 3 miles an hour.
Take the EAST EXIT out of Sky Harbor towards LOOP 202 - EAST, and take the exit onto CENTER PKWY towards DOWNTOWN TEMPE. Follow signs to CENTER PKWY, and then, once you reach Center Pkwy, turn left.
Follow Center Pkwy (briefly) to W Washington St, and turn right onto W Washington St; then take Washington St to Mill Ave, and turn right onto Mill Ave. You will then follow Mill Avenue into Downtown Tempe, where the University of Arizona, Tempe is located.