Answer: Well I recently found that the OTC drug percogesic stopped putting Phenyltoloxamine in its product and replaced it with Benadryl so I went on-line and sure enough Amazon I believe it was has an OTC drug called "Aceta-gesic"which has the Phenyltoloxamine citrate as well as the acetaminophen. It is a lot less expensive as well. Like $ 2.65 for a bottle of 100. ( I bought 4) I am now trying to find out where I can just purchase the Phenyltoloxamine citrate without the Tylenol. Due to the fact that I do not want to ingest it ( Tylenol) I have used these pills for great sleep for over 10 years and tried benadryl but it just isnt the same. If you or anyone knows where I can fine the Phenyltoloxamine Citrate I would sure like to know.. Gary H. in Florida
Answer: Citrate is a product / intermediate of the TCA Cycle (Which is responsible for breaking down Acetyl Coenzyme A ( Acetyl CoA ) into its final energy sources (1xGTP, 3xNADH, 1xFADH2) and byproducts CO2. Citrate generally remains in the Mitochondria (Where the TCA Cycle takes place), but may be transported to the cytosol. Citrate in the cytosol (The location of Glycolysis) acts to inhibit phosphofructokinase, which is an enzyme in the rate limiting step of Gl Save ycolysis involving the reaction of Fructose-6-phosphate to Fructose-1,6-bisphosphate. To summarize / Homework Answer: Increased cytosol levels of Citrate will decrease the rate of Glycolysis.
Answer: Indicationsanovulatory infertility-see notes aboveCautionssee notes above; polycystic ovary syndrome (cysts may enlarge during treatment, also risk of exaggerated response to usual doses), ovarian hyperstimulation syndrome, uterine fibroids, ectopic pregnancy, incidence of multiple births increased (consider ultrasound monitoring), visual symptoms (discontinue and initiate ophthalmological examination)CSM AdviceThe CSM has recommended that clomifene should not normally be used for longer than 6 cycles (possibly increased risk of ovarian cancer)Contra-indicationsovarian cysts, hormone-dependent tumours or abnormal uterine bleeding of undetermined causeHepatic impairmentavoid in severe liver diseasePregnancyexclude pregnancy before treatment; possible effects on fetal developmentBreast-feedingmay inhibit lactationSide-effectsvisual disturbances (withdraw), ovarian hyperstimulation (withdraw), hot flushes, abdominal discomfort, occasionally nausea, vomiting, depression, insomnia, breast tenderness, headache, intermenstrual spotting, menorrhagia, endometriosis, convulsions, weight gain, rashes, dizziness, hair loss
Answer: Klebsiella pneumoniae is a member of the Enterobacteriaceae family and is able to anaerobically use citrate as a source of Carbon because the citrate contains citritase, an enzyme that initiates a catabolic process. The carbonate and nitrogen of the citrate is broken down into acetate and oxalacetic acid, and then pyruvic acid and carbon dioxide. These products reacts with the ammonia (nitrogen and hydrogen) and sodium hydrogen carbonate compounds of the Citrate. The K. pneumoniae accumulates the alkalines and create a basic pH. (I think?)