Take I-77 SOUTH to I-95 SOUTH to SAVANNAH via I-26 EAST (EXIT 169A off I-26 to get onto I-95 SOUTH to SAVANNAH) in South Carolina.
Take I-95 SOUTH to West Palm Beach. The exits for West Palm Beach off I-95 are: EXIT 74 (45th St), 71 (Palm Beach Lakes Blvd), 70 [Okeechobee Blvd (FL-704)] (MAIN EXIT; TAKES YOU TO DOWNTOWN/CITYPLACE), 69 (Belvedere Rd), 68 [Southern Blvd (US-98)] and 66 [Forest Hill Blvd (FL-882)].
Answer: The driving distance is 205 miles. Since there is sometimes more than one route, including back roads, this is an approximate but accurate distance. It is based on the most well-known routes between these two locations.