Answer: The driving distance is 575 miles. Since there is sometimes more than one route, including back roads, this is an approximate but accurate distance. It is based on the most well-known routes between these two locations.
Answer: The driving distance between Tallahassee, FL and Key West, FL is approximately 640 miles. The driving time would be approximately 11 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)