Take I-75 NORTH from Ft. Myers all the way up to I-10 to JACKSONVILLE and TALLAHASSEE at EXIT 435, near Lake City; follow signs to I-10 EAST to JACKSONVILLE.
Take I-10 EAST to I-95 NORTH to SAVANNAH via I-295 NORTH to bypass JACKSONVILLE (EXIT 356 off I-10 to get onto I-295, follow signs to I-295 NORTH to SAVANNAH ; EXIT 35B off I-295 to get onto I-95 NORTH to SAVANNAH).
Take I-95 NORTH thru Florida and Georgia to I-26 WEST to COLUMBIA at EXIT 86B in SOUTH CAROLINA.
Take I-75 NORTH up to I-85 NORTH to GREENVILLE via I-675 NORTH (EXIT 227 off I-75 in GEORGIA) to get to I-285 EAST, and then I-285 around ATLANTA to I-85 NORTH to GREENVILLE off EXIT 33. To bypass MACON, take I-475 NORTH (EXIT 156 off I-75 in GEORGIA).
Take I-85 NORTH to I-26 WEST to ASHEVILLE off EXIT 70 in SOUTH CAROLINA.