Take I-75 SOUTH from Cincinnati all the way down to I-10 to JACKSONVILLE and TALLAHASSEE at EXIT 435 in FLORIDA; follow signs to I-10 WEST to TALLAHASSEE. To bypass ATLANTA, take I-285 WEST BYPASS (EXIT 259 off I-75 in GEORGIA to get onto I-285 ATLANTA BYPASS, follow signs to I-285 WEST BYPASS ; EXIT 58 off I-285 to get back onto I-75, follow signs to I-75 SOUTH to MACON and TAMPA). To bypass MACON, take I-475 SOUTH (EXIT 177 off I-75 in GEORGIA).
Take I-10 WEST to U.S. 231 to COTTONDALE and PANAMA CITY at EXIT 130; turn left off the exit ramp to get onto U.S. 231 SOUTH to PANAMA CITY.
Take U.S. 231 SOUTH to Panama City.
How many miles is it from Cape Canaveral Florida to Panama City Florida?
It is 410.5 miles from Cape Canaveral, Florida to Panama City,Florida. The approximate travel time by road is 6 hours and 9minutes.