Take PA-100 SOUTH from Pottstown to I-76 PENNSYLVANIA TURNPIKE (toll road). Once you are past the toll booth, follow signs to I-76 WEST to HARRISBURG.
Take I-76 WEST on the PENNSYLVANIA TURNPIKE to I-83 to YORK-BALTIMORE and HARRISBURG at EXIT 242 (HARRISBURG WEST exit). Once you are past the toll booth, stay left and go onto I-83 SOUTH to YORK and BALTIMORE.
Take I-83 SOUTH to I-95 SOUTH to WASHINGTON via I-695 (EXIT 11A off I-695 to get onto I-95 SOUTH to WASHINGTON) to bypass Baltimore.
Take I-95 SOUTH to Florence. The exits for Florence are EXITS 170-160. To bypass Richmond, take I-295 SOUTH (EXIT 84A off I-95 in VIRGINIA).
Answer: Given is the calculated distance as well as the driving travel time, which does not take into account driving conditions, traffic, etc. The distance between Florence, South Carolina and Lexington, South Carolina is 91.2 miles. The resulting travel time is 1 hour and 30 minutes.